Hippo-TAZ信号通路在乳腺癌及乳腺癌干细胞中的作用

摘要/Abstract

摘要：Hippo信号通路在调节器官生长、组织再生、肿瘤发生、发展中起重要作用，而含有PDZ结合模序转录共激活因子（TAZ）是其下游核心转录因子，参与整个信号通路的调控。近年来，研究者发现TAZ过表达与乳腺癌的发生、发展、预后都有着密切的关系。探讨Hippo信号通路中TAZ与乳腺癌及乳腺癌干细胞的关系，可为乳腺癌诊断和治疗提供新的思路。

关键词:乳腺肿瘤,肿瘤干细胞,Hippo信号通路,含有PDZ结合模序转录共激活因子

Abstract:Hippo signaling pathway plays an important role in the regulation of organ growth, tissue regeneration, tumor occurrence and development. Transcriptional coactivator with PDZbinding motif (TAZ) is the downstream transcription factor of Hippo signaling, participates in the regulation of the entire signaling pathway. In recent years, many studies have found that overexpression of TAZ has a close relationship with the occurrence, development and prognosis of breast cancer. Discussing the relationship of HippoTAZ with breast cancer and breast cancer stem cells may provide a new way for breast cancer diagnosis and treatment.

Key words:Breast neoplasms,Neoplastic stem cells,Hippo signaling,Transcriptional coactivator with PDZbinding motif

闫冰,卢颖,张春影,李青,毛俊,李连宏. Hippo-TAZ信号通路在乳腺癌及乳腺癌干细胞中的作用[J]. 国际肿瘤学杂志, 2016, 43(10): 779-782.

Yan Bing, Lu Ying, Zhang Chunying, Li Qing, Mao Jun, Li Lianhong. Roles of Hippo-TAZ signaling pathway in breast cancer and breast cancer stem cells[J]. Journal of International Oncology, 2016, 43(10): 779-782.

参考文献

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