AGGF1在肿瘤中的作用及其调控机制

国际肿瘤学杂志››2019,Vol. 46››Issue (3): 166-169.doi:10.3760/cma.j.issn.1673-422X.2019.03.007

AGGF1在肿瘤中的作用及其调控机制

沈夏波1李岩2王伟2

1安徽医科大学附属安徽省立医院肿瘤内科，合肥230001； 2中国科学技术大学附属第一
医院肿瘤内科，合肥230001

出版日期:2019-03-08发布日期:2019-05-17
通讯作者:王伟 E-mail:docweiwang@fsyy.ustc.edu.cn
基金资助:

国家自然科学基金（81201906）；安徽省自然科学基金（1708085QH177）

Roles of AGGF1 in tumor and its regulatory mechanisms

Shen Xiabo1, Li Yan2, Wang Wei2

1Department of Medical Oncology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, China; 2Department of Medical Oncology, First Affiliated Hospital of University of Science and Technology of China, Hefei 230001, China

Online:2019-03-08Published:2019-05-17
Contact:Wang Wei E-mail:docweiwang@fsyy.ustc.edu.cn
Supported by:

National Natural Science Foundation of China (81201906); Natural Science Foundation of Anhui Province of China (1708085QH177)

摘要/Abstract

摘要：血管生成因子含G补缀和FHA域1（AGGF1）是近年来鉴定出来的血管生成因子，其在血管内皮细胞高度表达，可表现出与血管内皮生长因子一样的功能，能够促进新生血管生成。近年来研究发现，AGGF1在肝癌、白血病、胶质瘤和胃癌等多种肿瘤中呈高表达。基于其可参与调控肿瘤血管生成、DNA修复和细胞自噬等机制，高表达AGGF1的肿瘤容易产生耐药及发生转移，其患者的生存与预后较AGGF1低表达的患者更差。深入了解AGGF1影响肿瘤血管生成的作用及具体的分子机制，可为抗肿瘤血管生成的治疗提供新策略。

关键词:肿瘤,新生血管化,病理性,DNA修复,自噬,AGGF1

Abstract:Angiogenic factor with G and FHA domain 1 (AGGF1) is an identified angiogenic factor in recent years, which is highly expressed in vascular endothelial cells and exhibits the same function as vascular endothelial growth factor, and can promote angiogenesis. Recently, it has been found that AGGF1 is highly expressed in various tumors such as liver cancer, leukemia, glioma and gastric cancer. Based on its participation in the regulation of tumor angiogenesis, DNA repair and autophagy, tumors with high expression of AGGF1 are prone to drug resistance and metastasis, and the survival and prognosis of patients are worse. Deep understanding of the roles of AGGF1 in tumor angiogenesis and its specific molecular mechanisms will provide new strategies for antitumor angiogenesis therapy in the future.

Key words:Neoplasms,Neovascularization, pathologic,DNA repair;,Autophagy,AGGF1

沈夏波，李岩，王伟. AGGF1在肿瘤中的作用及其调控机制[J]. 国际肿瘤学杂志, 2019, 46(3): 166-169.

Shen Xiabo, Li Yan, Wang Wei. Roles of AGGF1 in tumor and its regulatory mechanisms[J]. Journal of International Oncology, 2019, 46(3): 166-169.

参考文献

［1］ Tian XL, Kadaba R, You SA, et al. Identification of an angiogenic factor that when mutated causes susceptibility to KlippelTrenaunay syndrome［J］. Nature, 2004, 427(6975): 640645. DOI: 10.1038/nature02320. ［2］ Hu FY, Wu C, Li Y, et al. AGGF1 is a novel antiinflammatory factor associated with TNFαinduced endothelial activation［J］. Cell Signal, 2013, 25(8): 16451653. DOI: 10.1016/j.cellsig.2013.04.007. ［3］ Chen D, Li L, Tu X, et al. Functional characterization of KlippelTrenaunay syndrome gene AGGF1 identifies a novel angiogenic signaling pathway for specification of vein differentiation and angiogenesis during embryogenesis［J］. Hum Mol Genet, 2013, 22(5): 963976. DOI: 10.1093/hmg/dds501. ［4］ Li L, Chen D, Li J, et al. Aggf1 acts at the top of the genetic regulatory hierarchy in specification of hemangioblasts in zebrafish［J］. Blood, 2014, 123(4): 501508. DOI: 10.1182/blood201307514612. ［5］ Liu Y, Yang H, Song L, et al. AGGF1 protects from myocardial ischemia/reperfusion injury by regulating myocardial apoptosis and angiogenesis［J］. Apoptosis, 2014, 19(8): 12541268. DOI: 10.1007/s1049501410014. ［6］ Zhou B, Zeng S, Li N, et al. Angiogenic factor with G patch and FHA domains 1 is a novel regulator of vascular injury［J］. Arterioscler Thromb Vasc Biol, 2017, 37(4): 675684. DOI: 10.1161/ATVBAHA.117.308992. ［7］ Yao Y, Hu Z, Ye J, et al. Targeting AGGF1 (angiogenic factor with G patch and FHA domains 1) for blocking neointimal formation after vascular injury［J］. J Am Heart Assoc, 2017, 6(6): pii: e005889. DOI: 10.1161/JAHA.117.005889. ［8］ Xu Y, Zhou M, Wang J, et al. Role of microRNA27a in downregulation of angiogenic factor AGGF1 under hypoxia associated with highgrade bladder urothelial carcinoma［J］. Biochim Biophys Acta, 2014, 1842(5): 712725. DOI: 10.1016/j.bbadis.2014.01.007. ［9］ Wang W, Li GY, Zhu JY, et al. Overexpression of AGGF1 is correlated with angiogenesis and poor prognosis of hepatocellular carcinoma［J］. Med Oncol, 2015, 32(4): 131. DOI: 10.1007/s1203201505742. ［10］ Yao HH, Wang BJ, Wu Y, et al. High expression of angiogenic factor with Gpatch and FHA domain1 (AGGF1) predicts poor prognosis in gastric cancer［J］. Med Sci Monit, 2017, 23: 12861294. DOI: 10.12659/MSM.903248. ［11］ Tu J, Ying X, Zhang D, et al. High expression of angiogenic factor AGGF1 is an independent prognostic factor for hepatocellular carcinoma［J］. Oncotarget, 2017, 8(67): 111623111630. DOI: 10.18632/oncotarget.22880. ［12］陆艳荣, 阿衣古丽·哈热, 吴旻, 等. AGGF1在食管鳞癌组织的表达与临床特征及预后的关系［J］. 中国医师进修杂志, 2017, 40(8): 703706. DOI: 10.3760/cma.j.issn.16734904.2017.08.008. ［13］ Yang C, Zheng J, Xue Y, et al. The effect of MCM3APAS1/miR211/KLF5/AGGF1 axis regulating glioblastoma angiogenesis［J］. Front Mol Neurosci, 2018, 10: 437. DOI: 10.3389/fnmol.2017.00437. ［14］ He Q, Zhao L, Liu Y, et al. circSHKBP1 regulates the angiogenesis of U87 gliomaexposed endothelial cells through miR544a/FOXP1 and miR379/FOXP2 pathways［J］. Mol Ther Nucleic Acids, 2018, 10: 331348. DOI: 10.1016/j.omtn.2017.12.014. ［15］ Easwaran V, Lee SH, Inge L, et al. betacatenin regulates vascular endothelial growth factor expression in colon cancer［J］. Cancer Res, 2003, 63(12): 31453153. ［16］ Major MB, Roberts BS, Berndt JD, et al. New regulators of Wnt/betacatenin signaling revealed by integrative molecular screening［J］. Sci Signal, 2008, 1(45): ra12. DOI: 10.1126/scisignal.2000037. ［17］ Re OD, Anderssen E, Sandeck H, et al. Malignant pleural mesothelioma: genomewide expression patterns reflecting general resistance mechanisms and a proposal of novel targets［J］. Lung Cancer, 2010, 67(1): 5768. DOI: 10.1016/j.lungcan.2009.03.016. ［18］王楠, 徐美兰, 廖淑婷. AGGF1在结直肠癌细胞DNA损伤修复及化疗敏感性中的作用［J］. 南方医科大学学报, 2018, 38(7): 861866. DOI: 10.3969/j.issn.16734254.2018.07.15. ［19］ BravoSan Pedro JM, Kroemer G, Galluzzi L. Autophagy and mitophagy in cardiovascular disease［J］. Circ Res, 2017, 120(11): 18121824. DOI: 10.1161/CIRCRESAHA.117.311082. ［20］ Levy JMM, Towers CG, Thorburn A. Targeting autophagy in cancer［J］. Nat Rev Cancer, 2017, 17(9): 528542. DOI: 10.1038/nrc.2017.53. ［21］ Lu Q, Yao Y, Hu Z, et al. Angiogenic factor AGGF1 activates autophagy with an essential role in therapeutic angiogenesis for heart disease［J］. PLoS Biol, 2016, 14(8): e1002529. DOI: 10.1371/journal.pbio.1002529. ［22］马志元, 杨哲锋, 毕文忠. AGGF1在肝癌中的表达及与预后的关系［J］. 现代肿瘤医学, 2015, (9): 12411243. DOI: 10.3969/j.issn.16724992.2015.09.21. ［23］ Zabriskie MS, Antelope O, Verma AR, et al. A novel AGGF1PDGFRb fusion in pediatric Tcell acute lymphoblastic leukemia［J］. Haematologica, 2018, 103(2): e87e91. DOI: 10.3324/haematol.2017.165282. ［24］ Zhang Y, Gao Y, Zhang H, et al. PDGFRB mutation and tyrosine kinase inhibitor resistance in Phlike acute lymphoblastic leukemia［J］. Blood, 2018, 131(20): 22562261. DOI: 10.1182/blood201711817510. ［25］吴旻, 陆艳荣, 张瑾熔. AGGF1和HIF1α及VEGF表达与食管鳞癌放疗预后相关性研究［J］. 中华肿瘤防治杂志, 2016, 23(17): 11591164. DOI: 10.16073/j.cnki.cjcpt.2016.17.009. ［26］方瑜洁, 张明丽. 血管生成因子AGGF1表达与结肠癌患者预后关系的研究［J］. 胃肠病学, 2018, 23(6): 347350. DOI: 10.3969/j.issn.10087125.2018.06.006.

[1]	刘娜, 寇介丽, 杨枫, 刘桃桃, 李丹萍, 韩君蕊, 杨立洲.血清miR-106b-5p、miR-760联合低剂量螺旋CT诊断早期肺癌的临床价值[J]. 国际肿瘤学杂志, 2024, 51(6): 321-325.
[2]	杨蜜, 别俊, 张加勇, 邓佳秀, 唐组阁, 卢俊.局部晚期可切除食管癌新辅助治疗疗效及预后分析[J]. 国际肿瘤学杂志, 2024, 51(6): 332-337.
[3]	袁健, 黄燕华.Hp-IgG抗体联合血清DKK1、sB7-H3对早期胃癌的诊断价值[J]. 国际肿瘤学杂志, 2024, 51(6): 338-343.
[4]	陈红健, 张素青.血清miR-24-3p、H2AFX与肝癌患者临床病理特征及术后复发的关系研究[J]. 国际肿瘤学杂志, 2024, 51(6): 344-349.
[5]	郭泽浩, 张俊旺.PFDN及其亚基在肿瘤发生发展中的作用[J]. 国际肿瘤学杂志, 2024, 51(6): 350-353.
[6]	张百红, 岳红云.新作用机制的抗肿瘤药物进展[J]. 国际肿瘤学杂志, 2024, 51(6): 354-358.
[7]	许凤琳, 吴刚.EBV在鼻咽癌肿瘤免疫微环境和免疫治疗中的研究进展[J]. 国际肿瘤学杂志, 2024, 51(6): 359-363.
[8]	王盈, 刘楠, 郭兵.抗体药物偶联物在转移性乳腺癌治疗中的研究进展[J]. 国际肿瘤学杂志, 2024, 51(6): 364-369.
[9]	张蕊, 褚衍六.基于FIT与肠道菌群的结直肠癌风险评估模型的研究进展[J]. 国际肿瘤学杂志, 2024, 51(6): 370-375.
[10]	高凡, 王萍, 杜超, 褚衍六.肠道菌群与结直肠癌非手术治疗的相关研究进展[J]. 国际肿瘤学杂志, 2024, 51(6): 376-381.
[11]	王丽, 刘志华, 杨伟洪, 蒋凤莲, 李全泳, 宋浩杰, 鞠文东.ROS1突变肺腺鳞癌合并脑梗死为主要表现的Trousseau综合征1例[J]. 国际肿瘤学杂志, 2024, 51(6): 382-384.
[12]	刘静, 刘芹, 黄梅.基于SMOTE算法的食管癌放化疗患者肺部感染的预后模型构建[J]. 国际肿瘤学杂志, 2024, 51(5): 267-273.
[13]	杨琳, 路宁, 温华, 张明鑫, 朱琳.炎症负荷指数与胃癌临床关系研究[J]. 国际肿瘤学杂志, 2024, 51(5): 274-279.
[14]	王俊毅, 洪楷彬, 纪荣佳, 陈大朝.癌结节对结直肠癌根治性切除术后肝转移的影响[J]. 国际肿瘤学杂志, 2024, 51(5): 280-285.
[15]	张宁宁, 杨哲, 檀丽梅, 李振宁, 王迪, 魏永志.宫颈细胞DNA倍体分析联合B7-H4和PKCδ对宫颈癌的诊断价值[J]. 国际肿瘤学杂志, 2024, 51(5): 286-291.