以多发性脑梗死为首发症状的子宫内膜癌合并Trousseau综合征1例

国际肿瘤学杂志››2025,Vol. 52››Issue (10): 666-669.doi:10.3760/cma.j.cn371439-20250123-00114

以多发性脑梗死为首发症状的子宫内膜癌合并Trousseau综合征1例

徐枫¹^,², 韩琳³, 穆富玉⁴, 刘启萌¹, 李爱华¹()

¹聊城市人民医院妇产科，聊城 252000
²山东第二医科大学临床医学院，潍坊 261000
³聊城市人民医院病理科，聊城 252000
⁴聊城市人民医院影像科，聊城 252000

收稿日期:2025-01-23修回日期:2025-03-16出版日期:2025-10-08发布日期:2025-11-12
通讯作者:李爱华 E-mail:18663529788@126.com
基金资助:
山东第二医科大学附属医院科技发展项目(2024FYM142)

Received:2025-01-23Revised:2025-03-16Online:2025-10-08Published:2025-11-12

摘要/Abstract

摘要：

以多发性脑梗死为首发症状的子宫内膜癌合并Trousseau综合征极为罕见，文献报道较少，且其临床表现具有非特异性，较难诊断。现报道1例以多发性脑梗死为首发症状的子宫内膜癌合并Trousseau综合征病例，结合相关文献复习，以期提高对该类疾病的认识。

徐枫, 韩琳, 穆富玉, 刘启萌, 李爱华. 以多发性脑梗死为首发症状的子宫内膜癌合并Trousseau综合征1例[J]. 国际肿瘤学杂志, 2025, 52(10): 666-669.

图/表6

图1

图2

图3

图4

图5

图6

参考文献21

[1]	谢玲玲, 林仲秋. 《2024 NCCN子宫肿瘤临床实践指南(第1版)》解读[J].中国实用妇科与产科杂志,2023,39(11): 1122-1127. DOI:10.19538/j.fk2023110114.
[2]	Ikushima S, Ono R, Fukuda K, et al. Trousseau's syndrome: cancer-associated thrombosis[J].Jpn J Clin Oncol,2016,46(3): 204-208. DOI:10.1093/jjco/hyv165. pmid:26546690
[3]	Ichinokawa H, Nagasaki Y, Koike Y, et al. Left pneumonectomy for primary lung cancer with trousseau's syndrome[J].BMJ Case Rep,2021,14(3): e240927. DOI:10.1136/bcr-2020-240927.
[4]	Ishikawa M, Nakayama K, Ishibashi T, et al. Case series of cerebral infarction with trousseau's syndrome associated with malignant gynecological tumors[J].Mol Clin Oncol,2016,5(1): 138-142. DOI:10.3892/mco.2016.888. pmid:27330786
[5]	Taccone FS, Jeangette SM, Blecic SA. First-ever stroke as initial presentation of systemic cancer[J].J Stroke Cerebrovasc Dis,2008,17(4): 169-174. DOI:10.1016/j.jstrokecerebrovasdis.2008.01.007. pmid:18589335
[6]	Navi BB, Iadecola C. Ischemic stroke in cancer patients: a review of an underappreciated pathology[J].Ann Neurol,2018,83(5): 873-883. DOI:10.1002/ana.25227. pmid:29633334
[7]	Ling Y, Li Y, Zhang X, et al. Clinical features of trousseau's syndrome with multiple acute ischemic strokes[J].Neurol Sci,2022,43(4): 2405-2411. DOI:10.1007/s10072-021-05619-y.
[8]	Hirmerová J, Seidlerová J, Šubrt I, et al. Prevalence of cancer in patients with superficial vein thrombosis and its clinical importance[J].J Vasc Surg Venous Lymphat Disord,2022,10(1): 26-32. DOI:10.1016/j.jvsv.2021.05.006.
[9]	Tuar L, Usenik A, Turk B, et al. Mechanisms applied by protein inhibitors to inhibit cysteine proteases[J].Int J Mol Sci,2021,22(3): 997. DOI:10.3390/ijms22030997.
[10]	Jósa V, Brodszky V, Zaránd A, et al. The relationship between IL-6 and thrombocytosis accompanying gastrointestinal tumours[J].Prz Gastroenterol,2020,15(3): 215-219. DOI:10.5114/pg.2020.98538. pmid:33005266
[11]	Li H, Yu Y, Gao L, et al. Tissue factor: a neglected role in cancer biology[J].J Thromb Thrombolysis,2022,54(1): 97-108. DOI:10.1007/s11239-022-02662-0.
[12]	Moik F, Ay C. Venous and arterial thromboembolism in patients with cancer treated with targeted anti-cancer therapies[J].Thromb Res,2022,213 Suppl 1: S58-S65. DOI:10.1016/j.thromres.2022.01.004.
[13]	Goff BA, Agnew K, Neradilek MB, et al. Combining a symptom index, CA125 and HE4 (triple screen) to detect ovarian cancer in women with a pelvic mass[J].Gynecol Oncol,2017,147(2): 291-295. DOI:10.1016/j.ygyno.2017.08.020. pmid:28860006
[14]	Tsushima M, Metoki N, Hagii J, et al. D-dimer and C-reactive protein as potential biomarkers for diagnosis of trousseau's syndrome in patients with cerebral embolism[J].J Stroke Cerebrovasc Dis,2020,29(2): 104534. DOI:10.1016/j.jstrokecerebrovasdis.2019.104534.
[15]	Franco-Moreno A, Cabezón-Gutiérrez L, Palka-Kotlowsa M, et al. Evaluation of direct oral anticoagulants for the treatment of cancer-associated thrombosis: an update[J].J Thromb Thrombolysis,2019,47(3): 409-419. DOI:10.1007/s11239-018-1783-2.
[16]	Watanabe Y, Matsunuma K, Kaneda T. A case of successful anesthetic management in a patient with trousseau's syndrome who underwent surgery for malignant ovarian tumor[J].JA Clin Rep,2020,6(1): 32. DOI:10.1186/s40981-020-00339-2.
[17]	王丽, 刘志华, 杨伟洪, 等. ROS1突变肺腺鳞癌合并脑梗死为主要表现的Trousseau综合征1例[J].国际肿瘤学杂志,2024,51(6): 382-384. DOI:10.3760/cma.j.cn371439-20240215-00066.
[18]	Neilson LE, Rogers LR, Sundararajan S. Evaluation and treatment of a patient with recurrent stroke in the setting of active malignancy[J].Stroke,2019,50(1): e9-e11. DOI:10.1161/STROKEAHA.118.022088.
[19]	Russo V, Falco L, Tessitore V, et al. Anti-inflammatory and anticancer effects of anticoagulant therapy in patients with malignancy[J].Life (Basel),2023,13(9): 1888. DOI:10.3390/life13091888.
[20]	Frere C, Farge D, Schrag D, et al. Direct oral anticoagulant versus low molecular weight heparin for the treatment of cancer-associated venous thromboembolism: 2022 updated systematic review and meta-analysis of randomized controlled trials[J].J Hematol Oncol,2022,15(1): 69. DOI:10.1186/s13045-022-01289-1.
[21]	Van der Linden L, Vanassche T, Van Cutsem E, et al. Pharmacokinetic drug-drug interactions with direct anticoagulants in the management of cancer-associated thrombosis[J].Br J Clin Pharmacol,2023,89(8): 2369-2376. DOI:10.1111/bcp.15785. pmid:37170893

以多发性脑梗死为首发症状的子宫内膜癌合并Trousseau综合征1例

RichHTML

PDF

可视化

摘要/Abstract

引用本文

使用本文

图/表6

参考文献21

相关文章15

编辑推荐

Metrics

本文评价

[1]	王丽, 刘志华, 杨伟洪, 蒋凤莲, 李全泳, 宋浩杰, 鞠文东.ROS1突变肺腺鳞癌合并脑梗死为主要表现的Trousseau综合征1例[J]. 国际肿瘤学杂志, 2024, 51(6): 382-384.
[2]	凡梦思, 陆雅萍, 闫莉.子宫内膜癌前哨淋巴结假阴性患者的临床病理特征分析[J]. 国际肿瘤学杂志, 2023, 50(5): 274-279.
[3]	杨洪娟, 孙云川, 何新颖, 毕建强, 肖丽.子宫内膜中肾样腺癌1例并文献复习[J]. 国际肿瘤学杂志, 2023, 50(4): 255-256.
[4]	吕璐, 孙鹏飞, 崔腾璐.子宫内膜癌颈部淋巴结转移综合治疗1例并文献复习[J]. 国际肿瘤学杂志, 2023, 50(11): 701-704.
[5]	李宁, 张玢琪.免疫检查点抑制剂在子宫内膜癌中的应用[J]. 国际肿瘤学杂志, 2022, 49(2): 125-128.
[6]	鲁历历, 孙鹏飞, 叶斌强.放化疗联合盐酸安罗替尼治疗复发性子宫内膜癌1例[J]. 国际肿瘤学杂志, 2022, 49(12): 766-768.
[7]	徐秋月, 马咸梅, 岳琦.基于分子分型的子宫内膜癌免疫治疗[J]. 国际肿瘤学杂志, 2022, 49(11): 700-704.
[8]	林雅茹, 马晓林, 孙磊, 王桂春, 张琳, 路中.安罗替尼致小细胞肺癌患者脑梗死二例[J]. 国际肿瘤学杂志, 2021, 48(9): 575-576.
[9]	邓波儿, 孔为民.子宫内膜癌的表观遗传学研究进展[J]. 国际肿瘤学杂志, 2021, 48(3): 184-188.
[10]	黄于庭, 汪超.盐酸小檗碱联合表柔比星、顺铂对晚期子宫内膜癌的抗肿瘤效果[J]. 国际肿瘤学杂志, 2020, 47(9): 530-534.
[11]	赵小玲, 孔为民.二甲双胍在子宫内膜癌中的基础与临床研究现状[J]. 国际肿瘤学杂志, 2020, 47(7): 440-443.
[12]	王雪, 纪国欣, 纪超, 杨兴升.二甲双胍对合并2型糖尿病的Ⅰ型子宫内膜癌患者预后的影响[J]. 国际肿瘤学杂志, 2020, 47(7): 404-408.
[13]	周露秋, 刘先喜, 李艳, 毛熙光.Ⅰ型子宫内膜癌的预后危险因素分析[J]. 国际肿瘤学杂志, 2020, 47(6): 346-350.
[14]	罗春翠, 袁超燕, 陈庆芬.GOLPH3通过PI3K/AKT/GSK3β信号调控子宫内膜癌细胞的增殖与凋亡[J]. 国际肿瘤学杂志, 2020, 47(2): 65-69.
[15]	李美艳.HE4、OPN及uPA检测对子宫内膜癌患者诊断的临床意义[J]. 国际肿瘤学杂志, 2017, 44(5): 351-355.